OSA causes heart failing through relative hypertension during sleep. But CSA can be a heart failure sequela because maladaptive Cheyne-Stokes respiration decreases carbon dioxide levels in the setting of center failure hypercapnia. A variant of continuous positive airway pressure referred to as adaptive servo-ventilation therapy is effective at maintaining regular breathing patterns during Cheyne-Stokes respiration. The author conducted a sleep study on a 68-year-old former smoker with a past history of myocardial infarction, atrial fibrillation, pulmonary edema, and pacemaker placement.Latest GWAS – including a report released in the same issue of Character – have recognized a locus on chromosome 1p13 as strongly connected with both high LDL-C levels and incidence of MI and CHD. The results published in Character today display through a series of studies in patient cohorts and human-derived hepatocytes a common non-coding polymorphism at the 1p13 locus produces a novel transcription aspect binding site which in turn increases the expression of several liver genes.